Metabolism: A New Frontier in Cancer Research

The Microbiome in Precision Medicine: A New Approach to Cancer Treatment

Precision medicine is a new approach in medical sciences aimed at individualizing treatment, reducing adverse drug reactions (ADRs), and decreasing health care costs. Precision medicine is also able to maintain the health of individuals by regulating their composition of microorganisms (microbiota) using specific methods. Microbiota is the total stock of microbial species in different organs of...

Extracellular Vesicles Derived from Gastrointestinal Microbiota: A New Approach to Clinical Studies

Extracellular vesicles, naturally released from all cell types including bacteria, are of great importance in medical microbiology due to transporting a variety of biomaterials, enzymes, and virulence factors, regulating immunity, and having roles in colonization and initiation of signaling pathways. These vesicles are also secreted from microbiota in the gastrointestinal tract and affect the h...

Genetic suppression of tumor formation: a new frontier in cancer research.

Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?

An understanding of metabolic pathways based solely on biochemistry textbooks would underestimate the pervasive role of metabolism in essentially every aspect of biology. It is evident from recent work that many human diseases involve abnormal metabolic states--often genetically programmed--that perturb normal physiology and lead to severe tissue dysfunction. Understanding these metabolic outli...

Investigation on metabolism of cisplatin resistant ovarian cancer using a genome scale metabolic model and microarray data

Objective(s): Many cancer cells show significant resistance to drugs that kill drug sensitive cancer cells and non-tumor cells and such resistance might be a consequence of the difference in metabolism. Therefore, studying the metabolism of drug resistant cancer cells and comparison with drug sensitive and normal cell lines is the objective of this research. Material and Methods:Metabolism of c...

A new methodology for deriving the efficient frontier of stocks portfolios: An advanced risk-return model

In this paper after a general literature review on the concept of Efficient Frontier (EF), an important inadequacy of the Variance based models for deriving EFs and the high necessity for applying another risk measure is exemplified. In this regard for this study the risk measure of Lower Partial Moment of the first order is decided to replace Variance. Because of the particular shape of the pr...